Integrated Life Systems (ILS)
Innovations Transforming Biotechnology and Healthcare
Discover ILS
Transforming Diagnostics, Bioproduction, and Patient Care Through Patented Modalities
Integrated Life Systems (ILS) develops breakthrough technologies in detection, lysis, purification, and pain‑reduction. Our patented platforms simplify workflows, reduce costs, and improve outcomes across diabetes care, cell biology, molecular diagnostics, and biopharmaceutical manufacturing.
Our mission: Deliver first‑in‑class tools that make healthcare safer, faster, and more affordable.
Core Technologies Overview
Non‑Invasive Glucose Detection
DDLS Spectroscopy
Lysor® Ultrasonic Plate‑Wave Lysis
Large Volume Lysis
SmartGel® Purification Platform
CoolSyringe® Solid‑State Injection Pain Reduction
CoolLaser® Dermatology Cooling
PCR Analysis Algorithm
Non-Invasive Glucose Detection
Groundbreaking Advance
Needle‑Free. Reagent‑Free. Pain‑Free.
ILS has developed a patented non‑invasive glucose detection technology that eliminates blood draws, needles, reagent patches, and skin‑penetrating probes.
Why This Matters
Diabetes management requires frequent glucose checks. Needle pain, skin irritation, and compliance fatigue are major barriers. Even modern CGMs require probe insertion, reagent patches, and ongoing consumables.
ILS removes all of these burdens.
Note: Although continuous glucose monitors (CGM) reduce the frequency of skin puncture, they require the use of reagent patches and a probe (needle) that must be inserted into the patient's body, and be regularly replaced. In contrast, ILS devices do not require needles or reagent patches.
Clinical Impact
37 million Americans live with diabetes
96 million are pre‑diabetic
Needle‑free monitoring improves compliance and reduces complications
Technical Foundation
Our spectroscopy platform detects biophysical changes correlated with glucose levels — without skin penetration or chemical reactions.
Applications
Cancer cell identification
Circulating tumor cell detection
Rapid bacterial/viral characterization
Blood bag viability monitoring
Polymer, DNA, RNA mixture analysis
Advantages
Seconds‑to‑minutes detection
No reagents
No cell killing
High resolving power
Sealed, operator‑safe workflow
IDDLS Spectroscopy A New Detection Modality for Cells, Particles, and Macromolecules
DDLS detects macromolecular motion in an oscillating electric field, revealing biophysical properties such as size, charge, shape, and metabolic state.
How It Works
Electric field induces macromolecular motion
Laser detects scattered‑light modulation
Autocorrelation reveals biophysical properties
DDLS Spectroscopy
A Unique cell breakage (lysis) device. Lysis breaks cell membranes to release genetic and other interior cell materials of interest to researchers in general, medical, biotech, and other fields.
Lysis is a prerequisite for many biotech operations and diagnostics testing, e.g. PCR. The Lysor therefore addresses a significant market applications.
The Lysor was used in clinical and market units, with FDA (510k) approval
The ILS Lysor®
The ILS Lysor technology is based on the creation of standing ultrasonic plate waves. At particular geometries and frequencies, maximal/minimal energy “circles” are formed.
Sample Containers (usually closed tubes) are laced at Maximal Energy locations, which enhances lysis efficiency. The Lysor was used to release nucleic acids from Mycobaterium Tuberclosis (MTb), as a critical components in an MTB PCR assay..
Shown to efficiently lyse Mycobacterium tuberculosis (MTb) in few seconds.
Advantages of the ILS Lysor
The Lysor development presents a first, best-in-class device for cell lysis to release/extract desired cell components.
The Lysor advantages include: High Throughput as more sample tubes can be utilized with larger plates; No Cross Contamination with proprietary ILS sample tubes; Unique consumable, ILS sample vessel, ensures maximal transfer of vibrational energy to sample; and, Operator Safety, as no escaped aerosols.
ILS has been granted multiple patents for its non-invasive devices.
Superior Performance
The Lysor efficiently and quickly* lysed ‘tough’ microorganisms (e.g., Mycobacterium Tuberculosis, MTb); outperforming competitive lysis methods.
Bio Purification
Importance
Bio Purification is crucial
Manufacturing of pharmaceuticals, biotechnical, chemical, and food industries necessarily require purification to assure compounds' safety and efficacy. Purification can add substantial cost to delivering, e.g., a purified monoclonal antibody (MAb) drug, often constituting more than 70% of total manufacturing cost.
Critical Industries and Vast Markets Biopurification serves the pharmaceutical and biotech sectors which are pillars of the international economies with large sophisticated customer base.
Status Quo Challenges
Purification Products can be generally categorized as polymeric particles, e.g., gel beads, and membrane-based, e.g., hollow fibers.
Gel beads are widely used, they may have large capacity but exhibit poor flow characteristics. The major share of their capacity is reached by Diffusive Flow. Diffusion rates are significantly slow compared to Convective Flow. Large bead columns require high pressure to achieve appreciable flow which may deform delicate proteins and the beads themselves. Column packing and support require substantial time and skilled personnel.
Membrane‑based products, e.g., hollow fibers and flat sheets may be fast but their lower capacity limits scale up.
Solution: ILS SmartGel©
SmartGel Columns Applications
ILS has produced a variety of SmartGel purification columns to address extraction of a variety of classes of molecular species.
Columns with functionalities of ion exchangers, nucleic acids, affinity (antibody/antigen), heavy metal chelation, and hydrophilic filters have been prepared and utilized.
The columns demonstrated remarkable bind and release performance of compounds including immunoglobulins and other proteins, DNA/RNA, and multivalent ions. SmartGel were shown to exhibit outstanding performance compared to on-market competitors.
SmartGel columns are provided in capacities from milligrams to large scales up to kilograms. This facilitates migration and transferability from R&D to larger scale production, with substantial reduction cost and in process development time.
An exciting prospect of SmartGel technology is to address the extraction and recycling of heavy metals and other environmental hazards.
ILS introduced SmartGel, a novel purification matrix that creates an efficient "net" to specifically capture target molecules in complex fluids. The matrix is tailored to efficiently captures and release the target molecules.
SmartGel matrices are formed in various devices configured to operate in substantially convective flow. Combined with high capacity, fast convective flow enables SmartGel devices to rapidly extract and concentrate molecules from very dilute/large volumes.
Major Improvements for Large-Scale Purification:The challenges with large scale for the now routine and life saving biopharma drugs can be addressed and overcome using SmartGel, with high capacity and significantly higher fluid flow rates at significantly low pressure. This enables purifying delicate protein drugs and bio-pharmaceuticals while avoiding degradation of delicate biomolecules.
Flexibility: A wide range of SmartGel products are manufactured using essentially the same process, with capacity from milligrams quantities(R&D) to industrial scale. This eases migration from R&D to larger scale, substantially reduce process cycle duration.
Wide Application Fields: Proteins, Nucleic acids (DNA & RNA); Heavy metal ions, Filters, etc.
Ease of Use: The availability of plug-in SmartGel columns provides a substantial market advantage over bulk gel particles due to time savings in column preparation and validation.
Lower Consumables, Labor, and Operating Cost: Columns are provided in ready-to-use or customizable formats; lower capex; and smaller foot print. SmartGel columns also enjoy a strong margin advantage versus poured gel beads.
SmartGel Columns: Extraordinary Advantages
Nerve endings in skin layers are sensitive to medical treatments that penetrate/interact with the skin. Pain may be severe enough to require administration of pain relief drugs, such as Novocain. Avoiding pain relieving drugs is preferable, whenever possible.
Importantly, the associated pain levels can cause patient apprehension, discomfort, and may interfere with medication compliance. This is relevant in case diabetics, and particularly diabetic children.
Skin Cooling Devices
Cooling of the skin has been observed to lessen pain associated with hypodermic injections. Skin cooling can improve patient experience during hypodermic injections.
Cooling skin is attempted by methods including evaporative anesthetics (vapocoolant), where a volatile anesthetic is sprayed on the area of injection (Link). Another method uses a distraction device (for children) with a buzzing sound.
Other methods include use of refrigerated needles (needles stored in a freezer), use of cooling gas, and use of chemical (endothermic) reactions, e.g. ammonium nitrate and water (Link).
CoolSyringe Help Reduce Pain in Many Procedures
Fear of Needle: Needle Phobia is not exhibited by children only; over 20% of adults may temporarily lose consciousness around the time of a needle procedure (Wikipedia).
Diabetes: 37.3 million people, or 11.3% of the U.S. (Link). population, have diabetes. An estimated 28.7 million people – had diagnosed diabetes. Approximately 8.6 million people have diabetes but have not yet been diagnosed. In addition to needle apprehension, frequent injections will likely irritate/cause irritation and multiple skin bumps.
Cosmetics: Filler injections; e.g., Botox/Others. Note that Botox is also prescribed for migraines. Numerous other injectable medications/cosmetics routinely enter the market, e.g.,:
Childhood Vaccines: 26 vaccine shots are given per child in child's first year currently in the USA, where infant/other childhood vaccine shots are estimated at >100 million per year.
Seasonal Vaccination: Annual flu shots are administered to about 50% of the population; >100 million injections/year.
COVID-19: By the end of 2022, multiple billions of COVID-19 doses have been administered worldwide; 600 million in the USA.
CoolSyringe: Easy, Cool Pain Relief
CoolSyringe offers advantages currently unavailable in commercial or clinical devices that address pain reduction via skin cooling. This may be concluded from the competition outlined above, and after patent and literature searches.
CoolSyringe’s advantages include
Solid State: no fluids, chemical reactions, or evaporative anesthetics;
Easy of Use: Hand-held; Delivered Ready to use;
Battery-Operated, Rechargeable;
Fast skin cooling (seconds);
Safety Features include low voltage operation, temperature monitoring indicators, automatic shutoff.
ILS has been granted multiple patents for its skin cooling devices.
CoolLaser alleviates pain during dermatological procedures involving electromagnetic sources, e.g., lasers. CoolLaser’s applications include procedures such as hair and tattoo removal, skin de-pigmentation and other dermatological cosmetic procedures. These are widely used applications, for example, there are over 1 million hair removal procedures yearly in the USA.
Currently available laser devices used in cosmetic treatments with cooling options, particularly in professional medical settings, are quite large, use liquid or gas for cooling, and require professional maintenance (Link).
Note: ILS does not address manufacturing the lasers or other sources of electromagnetic radiation. ILS niche is to provide simple, portable and elegant cooling implements for patient comfort and pain reduction during cosmetic procedures.
CoolLaser offers advantages to afford its use by medical professional and home users with features including: Solid state construction; fast skin cooling, hand-held small form factor, battery-operation, no fluids or cold gases used, and use safety.
For more information on CoolLaser, please contact ILS.
